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Volume 358:2076-2077 May 8, 2008 Number 19
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More on Subgroup Analyses in Clinical Trials

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by Wang, R.
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To the Editor: With regard to the article by Wang et al. (Nov. 22 issue), it is increasingly recognized that subgroup analyses in clinical trials are sometimes misused and require appropriate presentation and cautious interpretation.1,2 However, we would recommend that one type of subgroup analysis (in large "positive" trials or meta-analyses) be performed more often. That is, from a prognostic model, one categorizes patients into several ordered risk groups and estimates the absolute risk reduction in each group. For instance, the Third Randomized Intervention Treatment of Angina (RITA-3) trial,3 involving patients with acute coronary syndromes, showed an overall reduction in . . . [Full Text of this Article]



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