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Volume 358:2077-2078 May 8, 2008 Number 19
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Dual Inheritance of Sudden Death from Cardiovascular Causes

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To the Editor: The long-QT syndrome and catecholaminergic polymorphic ventricular tachycardia are the most common inherited cardiac channelopathies.1 Although the disease mechanisms for these two disorders differ, the resulting arrhythmias are similar, and both are triggered by sympathetic stimulation.2,3 We identified the coexistence of the two diseases in one family.

A family with a history of recurrent sudden death was studied. During the past 30 years, nine members have died suddenly between 7 and 40 years of age. A borderline QT interval corrected for heart rate (QTc) of 450 msec in one asymptomatic relative (identified as V-1 in Figure 1. . . [Full Text of this Article]



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