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Volume 358:105-107 January 10, 2008 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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It may happen soon. A patient, perhaps one you have known for years, who is overweight and does not exercise regularly, shows up in your office with an analysis of his whole genome at multiple single-nucleotide polymorphisms (SNPs). His children, who were concerned about his health, spent $1,000 to give him the analysis as a holiday gift. The test report states that his genomic profile is consistent with an increased risk of both heart disease and diabetes, and because the company that performed the analysis stated that the test was "not a clinical service to be used as the basis . . . [Full Text of this Article]

Source Information

Dr. Hunter is a professor in the Departments of Epidemiology and Nutrition at the Harvard School of Public Health, Boston, and a statistical consultant to the Journal. Dr. Khoury is the director of the National Office of Public Health Genomics at the Centers for Disease Control and Prevention, Atlanta. Dr. Drazen is the editor-in-chief of the Journal. The opinions expressed in this article do not necessarily reflect the views of the Department of Health and Human Services.

An interview with Dr. Muin Khoury, director of the National Office of Public Health Genomics at the Centers for Disease Control and Prevention, can be heard at www.nejm.org.

Related Letters:

Letting the Genome Out of the Bottle
Haga S. B., Willard H. F., Audeh M. W., Hunter D. J., Khoury M. J., Drazen J. M.
Extract | Full Text | PDF  
N Engl J Med 2008; 358:2184-2185, May 15, 2008. Correspondence

This article has been cited by other articles:

• Haga, S. B., Willard, H. F., Audeh, M. W., Hunter, D. J., Khoury, M. J., Drazen, J. M. (2008). Letting the Genome Out of the Bottle. NEJM 358: 2184-2185 [Full Text]  
• Roth, S. M. (2008). Last Word on Viewpoint: Perspective on the future use of genomics in exercise prescription. J. Appl. Physiol. 104: 1254-1254 [Full Text]  
• Tracy, E. E. (2008). Are Doctors Prepared for Direct-to-Consumer Advertising of Genetic Tests?. Obstet Gynecol 111: 991-991 [Full Text]  
• Feero, W. G., Guttmacher, A. E., Collins, F. S. (2008). The Genome Gets Personal--Almost. JAMA 299: 1351-1352 [Full Text]