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Previous Volume 358:169-176 January 10, 2008 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's clinical recommendations.

After the sudden death of a 13-year-old girl while she was playing basketball, her family comes to the clinic for medical evaluation (Figure 1). Her parents' resting electrocardiograms (ECGs) are normal, but her 9-year-old sister's ECG shows an abnormally long QT interval. There is a history of recurrent syncope in female relatives of the maternal grandmother, but there is no . . . [Full Text of this Article]

The Clinical Problem

Strategies and Evidence

Diagnosis

Genetic Testing

Risk Stratification

Therapy

Areas of Uncertainty

Guidelines

Conclusions and Recommendations

Source Information

From the Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville.

Address reprint requests to Dr. Roden at the Departments of Medicine and Pharmacology, Oates Institute for Experimental Therapeutics, Vanderbilt University School of Medicine, 1285 Medical Research Building IV, Nashville, TN 37232-0575, or at dan.roden@vanderbilt.edu.

Related Letters:

Long-QT Syndrome
Marijon E., Combes N., Albenque J. P., Kapoor J. R., Roden D. M.
Extract | Full Text | PDF  
N Engl J Med 2008; 358:1967-1968, May 1, 2008. Correspondence

This article has been cited by other articles:

• Marijon, E., Combes, N., Albenque, J. P., Kapoor, J. R., Roden, D. M. (2008). Long-QT syndrome.. NEJM 358: 1967-1968 [Full Text]  
• Berul, C. I. (2008). Congenital Long-QT Syndromes: Who's at Risk for Sudden Cardiac Death?. Circulation 117: 2178-2180 [Full Text]