This Journal feature begins with a case vignette highlightinga common clinical problem. Evidence supporting various strategiesis then presented, followed by a review of formal guidelines,when they exist. The article ends with the author's clinicalrecommendations.
After the sudden death of a 13-year-old girl while she was playingbasketball, her family comes to the clinic for medical evaluation(Figure 1). Her parents' resting electrocardiograms (ECGs) arenormal, but her 9-year-old sister's ECG shows an abnormallylong QT interval. There is a history of recurrent syncope infemale relatives of the maternal grandmother, but there is no. . . [Full Text of this Article]
The Clinical Problem
Strategies and Evidence
Diagnosis
Genetic Testing
Risk Stratification
Therapy
Areas of Uncertainty
Guidelines
Conclusions and Recommendations
Source Information
From the Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville.
Address reprint requests to Dr. Roden at the Departments of Medicine and Pharmacology, Oates Institute for Experimental Therapeutics, Vanderbilt University School of Medicine, 1285 Medical Research Building IV, Nashville, TN 37232-0575, or at dan.roden@vanderbilt.edu.
Related Letters:
Long-QT Syndrome
Marijon E., Combes N., Albenque J. P., Kapoor J. R., Roden D. M.
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N Engl J Med 2008;
358:1967-1968, May 1, 2008.
Correspondence
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