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Previous Volume 358:190-192 January 10, 2008 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Owing to their immunosuppressive and antiproliferative effects, sirolimus (also called rapamycin) and related drugs are being evaluated as part of many transplant immunosuppresion regimens, as well as for a plethora of medical conditions such as type 1 diabetes, macular degeneration, coronary artery disease, and metastatic or refractory cancers of the breast, prostate, lung, and liver, to name but a few.

The effects of sirolimus are mediated by its inhibition of the curiously named cytoplasmic protein mammalian target of rapamycin (mTOR), a ubiquitous serine–threonine kinase that is intimately involved in the regulation of protein synthesis, cell growth, cytoskeletal organization, and other . . . [Full Text of this Article]

Source Information

From the Division of Pediatric Nephrology (E.P.) and the Departments of Neurology and Pediatrics (E.T.), Massachusetts General Hospital, Boston.

This article has been cited by other articles:

• Weichhart, T, Saemann, M D (2008). The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications. Ann Rheum Dis 67: iii70-iii74 [Abstract] [Full Text]  
• Rosner, M., Hengstschlager, M. (2008). Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1. Hum Mol Genet 17: 2934-2948 [Abstract] [Full Text]  
• Egan, J. J., Remund, K. F., Corris, P., Bissler, J. J., Young, L. R., McCormack, F. X. (2008). Sirolimus for Lymphangioleiomyomatosis Lesions. NEJM 358: 1963-1964 [Full Text]