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Volume 358:199-200 January 10, 2008 Number 2
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Diagnostic Potential of Serum VEGF-D for Lymphangioleiomyomatosis

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To the Editor: Lymphangioleiomyomatosis is a rare, progressive, frequently fatal cystic lung disease that affects women almost exclusively.1,2 It occurs in up to 40% of women with the tuberous sclerosis complex, a tumor-suppressor syndrome associated with seizures, cognitive impairment, and hamartomas in multiple organs, and can also occur in a nonheritable sporadic form that involves only the lung, lymphatics, and kidney.3 The presence of the tuberous sclerosis complex or fat-containing renal hamartomas called angiomyolipomatas in a woman with characteristic cystic changes on a high-resolution computed tomographic (CT) scan of the chest is considered to be diagnostic of lymphangioleiomyomatosis. However, half . . . [Full Text of this Article]


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