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This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented. The article ends with the author's clinical recommendations.
A busy 28-year-old professional consults his physician for advice on long-standing hay fever. He reports having itchy eyes and an itchy nose, lacrimation, sneezing, rhinorrhea, and nasal congestion during the summer months. In previous years, he tried various antihistamines
The Clinical Problem
Pathophysiology and Effect of Therapy
Clinical Evidence
Clinical Use
Adverse Effects
Areas of Uncertainty
Guidelines
Recommendations
Source Information
From the Department of Respiratory Medicine, Brighton General Hospital, Brighton, United Kingdom.
Address reprint requests to Dr. Frew at the Department of Respiratory Medicine, Brighton General Hospital, Brighton BN2 3EW, United Kingdom, or at anthony.frew@bsuh.nhs.uk.
Related Letters:
Sublingual Immunotherapy
Bonnin A. J., Zacharias D. M., Frew A.
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N Engl J Med 2008;
359:869-870, Aug 21, 2008.
Correspondence
This article has been cited by other articles:
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