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Previous Volume 358:2299-2300 May 22, 2008 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Cohen et al. (March 23, 2006, issue)¹ describe a missense variant in the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene that was associated with reductions in low-density lipoprotein (LDL) cholesterol levels and in the risk of coronary heart disease. They report that among whites, the L allele at R46L (rs11591147) was associated with a 15% reduction in plasma levels of LDL cholesterol and a decreased risk of incident coronary heart disease (hazard ratio, 0.50; 95% confidence interval [CI], 0.32 to 0.79; P=0.003). Although the association of R46L with reduced LDL cholesterol levels has been convincingly . . . [Full Text of this Article]

This article has been cited by other articles:

• Horton, J. D., Cohen, J. C., Hobbs, H. H. (2009). PCSK9: a convertase that coordinates LDL catabolism. J. Lipid Res. 50: S172-S177 [Abstract] [Full Text]