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Previous Volume 358:2403-2405 May 29, 2008 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Osteoporosis is a common skeletal disorder characterized by compromised bone strength and increased bone fragility, affecting up to 40% of postmenopausal women and 15% of men.¹ Its clinical significance lies in the occurrence of osteoporotic fractures — most commonly involving the forearm, the vertebral bodies, and the hip — with considerable morbidity, mortality, and cost to the individual and the community.²

Many factors, including age, menopausal status, smoking, physical activity, diet, coexisting diseases, and pharmacologic treatments, influence the risk of osteoporosis, but one of the most clinically important risk factors is a family history of the disorder. As in other . . . [Full Text of this Article]

Source Information

From the Divisions of Endocrinology and Genetics and Program in Genomics, Children's Hospital, Boston, and the Broad Institute of Harvard and MIT, Cambridge, MA (J.N.H.); the Department of Genetics, Harvard Medical School, Boston (J.N.H.); and the Department of Internal Medicine, University of Siena, Siena, Italy (L.G.).

This article (10.1056/NEJMe0803046) was published at www.nejm.org on April 29, 2008.

This article has been cited by other articles:

• Weiss, K. M. (2008). Tilting at Quixotic Trait Loci (QTL): An Evolutionary Perspective on Genetic Causation. Genetics 179: 1741-1756 [Abstract] [Full Text]