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Volume 358:2409-2411 May 29, 2008 Number 22
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Hutchinson–Gilford Progeria Syndrome

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by Merideth, M. A.
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To the Editor: In an otherwise elegant clinical description of the Hutchinson–Gilford progeria syndrome by Merideth and colleagues (Feb. 7 issue),1 we take exception to the authors' suggestion that their findings have overarching significance with respect to an understanding of normal aging. Although some of the changes that characterize the Hutchinson–Gilford progeria syndrome look like aging, other characteristic features of the syndrome (e.g., elevated platelet counts, prolonged prothrombin times, and functional oral deficits) do not. Moreover, certain prominent features of human aging — for example, the activation of inflammatory pathways — are not typical of the Hutchinson–Gilford progeria syndrome.

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