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Previous Volume 358:2648-2649 June 12, 2008 Number 24 Next

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To the Editor: Christopoulos et al. (March 6 issue)¹ report a case of primary ovarian insufficiency associated with imatinib. Although the data provided are suggestive of primary ovarian insufficiency, the cause-and-effect relationship is speculative, not reaching the "probable" level on an objective causality-assessment scale.² It is noteworthy that fertility in female rats is not adversely affected by imatinib, and pregnancy in women taking imatinib has occurred.^3,4 Also, despite the expanding use of imatinib, no other cases of primary ovarian insufficiency have been reported. All these facts, along with the presence of follicles in the patient's ovaries on ultrasonography and the . . . [Full Text of this Article]

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Primary Ovarian Insufficiency Associated with Imatinib Therapy
Christopoulos C., Dimakopoulou V., Rotas E.
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N Engl J Med 2008; 358:1079-1080, Mar 6, 2008. Correspondence

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