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Volume 358:2649-2651 June 12, 2008 Number 24
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Propranolol for Severe Hemangiomas of Infancy

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To the Editor: Despite their self-limited course, infantile capillary hemangiomas can impair vital or sensory functions or cause disfigurement. Corticosteroids are the first line of treatment for problematic infantile capillary hemangiomas1,2; other options include interferon alfa3 and vincristine.1 We have observed that propranolol can inhibit the growth of these hemangiomas. Our preliminary data from 11 children are summarized in Table 1 in the Supplementary Appendix, available with the full text of this letter at www.nejm.org.

The first child had a nasal capillary hemangioma. Despite corticosteroid treatment, the lesion was stabilized but obstructive hypertrophic myocardiopathy developed, so the patient . . . [Full Text of this Article]


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More on Propranolol for Hemangiomas of Infancy
Siegfried E. C., Keenan W. J., Al-Jureidini S., Léauté-Labrèze C., de la Roque E. D., Taïeb A.
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N Engl J Med 2008; 359:2846-2847, Dec 25, 2008. Correspondence

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