To the Editor: Despite their self-limited course, infantilecapillary hemangiomas can impair vital or sensory functionsor cause disfigurement. Corticosteroids are the first line oftreatment for problematic infantile capillary hemangiomas1,2;other options include interferon alfa3 and vincristine.1 Wehave observed that propranolol can inhibit the growth of thesehemangiomas. Our preliminary data from 11 children are summarizedin Table 1 in the Supplementary Appendix, available with thefull text of this letter at www.nejm.org.
The first child had a nasal capillary hemangioma. Despite corticosteroidtreatment, the lesion was stabilized but obstructive hypertrophicmyocardiopathy developed, so the patient . . . [Full Text of this Article]
Sans, V., de la Roque, E. D., Berge, J., Grenier, N., Boralevi, F., Mazereeuw-Hautier, J., Lipsker, D., Dupuis, E., Ezzedine, K., Vergnes, P., Taieb, A., Leaute-Labreze, C.
(2009). Propranolol for Severe Infantile Hemangiomas: Follow-Up Report. Pediatrics
124: e423-e431
[Abstract][Full Text]
Itani, M. H., Fakih, H.
(2009). Response of facial haemangioma to oral propranolol. BMJ Case Reports
2009: bcr0120091476-bcr0120091476
[Abstract][Full Text]
Patnaik, S. K., Sondhi, V.
(2009). Treating subglottic haemangioma with methylprednisolone and interferon{alpha}-2a. BMJ Case Reports
2009: bcr1120081214-bcr1120081214
[Abstract][Full Text]
Sidbury, R.
(2009). Hypothalamic-Pituitary-Adrenal Axis Suppression in Systemic Glucocorticoid-Treated Infantile Hemangiomas: Putting the Risk Into Context. Arch Dermatol
145: 319-320
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Siegfried, E. C., Keenan, W. J., Al-Jureidini, S., Leaute-Labreze, C., de la Roque, E. D., Taieb, A.
(2008). More on Propranolol for Hemangiomas of Infancy. NEJM
359: 2846-2847
[Full Text]