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Previous Volume 358:2827-2829 June 26, 2008 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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For more than half a century, heparin and vitamin K antagonists have defined anticoagulant therapy for the short-term and long-term management, respectively, of thrombotic disorders of the venous system. The history of their development is instructive. In 1922, at the annual meeting of the American Physiological Society, William H. Howell of Johns Hopkins Medical School presented an extraction protocol for isolating heparin preparations. Dicoumarol, a bacterial antagonist of vitamin K in spoiled sweet clover, was recognized as the agent responsible for a fatal hemorrhagic disease in livestock by Karl Link and Wilhelm Schoeffel of the University of Wisconsin. In both . . . [Full Text of this Article]

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From the Division of Cardiology, University of Freiburg, Freiburg, Germany (J.L.); and the Cardiovascular Thombosis Center, Duke University Medical Center, Durham, NC (R.C.B.).

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Rivaroxaban for Thromboprophylaxis
Schuman E. P., Lippi G., Franchini M., Targher G., Lotke P. A., ten Cate H., Hamulyak K., Geerts W., the RECORD 1 and RECORD 3 Investigators , Lassen M. R., Ageno W., Turpie A. G.G., Lohrmann J., Becker R. C.
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N Engl J Med 2008; 359:2174-2176, Nov 13, 2008. Correspondence

This article has been cited by other articles:

• Schuman, E. P., Lippi, G., Franchini, M., Targher, G., Lotke, P. A., ten Cate, H., Hamulyak, K., Geerts, W., the RECORD 1 and RECORD 3 Investigators, , Lassen, M. R., Ageno, W., Turpie, A. G.G., Lohrmann, J., Becker, R. C. (2008). Rivaroxaban for thromboprophylaxis.. NEJM 359: 2174-2175 [Full Text]