In this issue of the Journal, three articles describe severalorgan-transplant recipients in whom allografts have maintainedgood function for up to 5 years without immunosuppressive treatment.1,2,3In two articles concerning combined kidney and hematopoieticstem-cell transplantation, the authors attributed the successfuloutcome in their patients to the cotransplantation of donorstem cells.1,2
The third report, by Alexander et al., concerns a young girlwho received a completely HLA-mismatched liver from a deceasedmale donor but did not receive a donor stem-cell infusion.3The cause of the fulminant hepatic failure with which the patientpresented was never firmly established. However, . . . [Full Text of this Article]
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From the Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center Montefiore, Pittsburgh.
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