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Correspondence
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Volume 358:649-650 February 7, 2008 Number 6
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Malignant Melanoma with Metastatic Rhabdomyosarcomatoid Transdifferentiation

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To the Editor: We report on the case of a 41-year-old man with a 2.1-cm primary malignant melanoma of the skin, located on the crown of the head. The tumor was stage pT4 (with invasion of contiguous structures), Clark level V, and 6 mm in thickness, with classic morphologic and immunohistochemical features, including strong positivity for the malignant melanoma–specific immunomarkers S100 and MART1 (Figure 1A).

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Figure 1. Morphologic and Immunohistochemical Features of Primary Malignant Melanoma in a Patient with Metastatic Rhabdomyosarcoma.

In primary malignant melanoma, atypical melanocytes show strong immunoreactivity to the melanoma markers S100 and MART1 (Panel A), whereas . . . [Full Text of this Article]

 



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