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Previous Volume 358:737-739 February 14, 2008 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Sixty-five years after Leo Kanner first described autism,¹ we are beginning to move beyond description of this clinically heterogeneous neurobehavioral syndrome toward a deeper understanding of its biologic complexity. In areas such as genetics and neuroscience, researchers have joined the search for objective measures to elucidate autism's pathogenesis.

It has become clear that the solutions to autism will be neither simple nor uniform among patients with various autistic syndromes. At least 60 different genetic, metabolic, and neurologic disorders have been associated with autism and involve approximately 10% of patients, whose clinical presentations frequently vary, even among those with known disorders.² . . . [Full Text of this Article]

Source Information

From the Howard Hughes Medical Institute and the Department of Genome Sciences, University of Washington, Seattle (E.E.E.); and the Kennedy Krieger Institute and Johns Hopkins University, Baltimore (A.W.Z.).

This article (10.1056/NEJMe0708756) was published at www.nejm.org on January 9, 2008.

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• Caronna, E B, Milunsky, J M, Tager-Flusberg, H (2008). Autism spectrum disorders: clinical and research frontiers. Arch. Dis. Child. 93: 518-523 [Abstract] [Full Text]