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Previous Volume 358:753-754 February 14, 2008 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Two independent, well-powered studies have recently identified the interleukin-7 receptor (IL7RA) gene as a susceptibility gene for multiple sclerosis,^1,2 thus extending and confirming earlier observations.^3,4 A functional, nonsynonymous single-nucleotide polymorphism (SNP), rs6897932, located in the alternatively spliced sixth exon of the gene, was highlighted as the susceptibility-modifying polymorphism, with the C allele increasing the risk of disease (odds ratio, approximately 1.2).^1,2

We genotyped nine haplotype-tagging SNPs in IL7RA in two independent case–control collections from Olmsted County, Minnesota, and Belfast, Northern Ireland, neither of which, to our knowledge, has previously been tested for IL7RA (Table . . . [Full Text of this Article]

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