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A 43-year-old woman presented with a 10-month history of an urticarial rash induced by cold, particularly when she was swimming. A clinical diagnosis of cold-induced urticaria was made. The diagnosis was confirmed by inducing an urticarial weal with an ice cube placed on the forearm for 5 minutes (Panel A). Initially, only erythema was apparent, but as the skin warmed, a typical urticarial lesion developed (Panel B and close-up view in Panel C), gradually filling in from the periphery of the cooled area (Panel D). The patient was treated with daily nonsedating antihistamines and was warned of the risk of . . . [Full Text of this Article] |
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