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Previous Volume 359:92-93 July 3, 2008 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Kathiresan and coworkers (March 20 issue)¹ find that a genotype score of nine, which was crafted from a combination of four single-nucleotide polymorphisms (SNPs) affecting high-density lipoprotein (HDL) cholesterol and five SNPs influencing low-density lipoprotein (LDL) cholesterol, is an independent risk factor for incident cardiovascular disease. Similarly, Willer et al. recently showed that 11 SNPs associated with elevated LDL levels (most of which overlap with the genes included in the article by Kathiresan et al.) increase the risk of coronary artery disease.² In contrast, the HDL-modulating SNPs reported by Willer et al. were not associated with the . . . [Full Text of this Article]

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