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Previous Volume 359:99-100 July 3, 2008 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Mullen et al. (Feb. 7 issue)¹ report on two cases of melanoma in patients with multiple sclerosis who received natalizumab. Their letter shows the limited interpretability of individual case reports in establishing cause-and-effect relationships. In response to this letter, we performed a meta-analysis of safety data from clinical trials of natalizumab. The incidence of melanoma was similar among patients who received natalizumab (3 of 4250 [0.07%]) as compared with those who received placebo (2 of 2059 [0.10%]). Rates of melanoma followed a similar pattern: 0.419 per 1000 patient-years among persons who received natalizumab versus 0.823 per 1000 . . . [Full Text of this Article]

Related Letters:

Melanoma Complicating Treatment with Natalizumab for Multiple Sclerosis
Mullen J. T., Vartanian T. K., Atkins M. B.
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N Engl J Med 2008; 358:647-648, Feb 7, 2008. Correspondence

This article has been cited by other articles:

• Yaldizli, O., Putzki, N. (2009). Review: Natalizumab in the treatment of multiple sclerosis. Therapeutic Advances in Neurological Disorders 2: 115-128 [Abstract]