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Correspondence
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Volume 359:1074-1076 September 4, 2008 Number 10
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Fatal Oseltamivir-Resistant Influenza Virus Infection

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To the Editor: The incidence of influenza A (H1N1) viruses that carry the neuraminidase H274Y mutation has increased by 30% this year in the Netherlands.1 Influenza A (H1N1) viruses that carry this mutation are resistant to oseltamivir but remain sensitive to zanamivir.2 However, these mutant viruses are considered to have attenuated pathogenicity.3,4

A 67-year-old man who had received a diagnosis of chronic lymphocytic leukemia 3 years earlier was admitted to the hospital because of dyspnea, dry cough, and fever. One week before admission, he had received a course of cyclophosphamide, vincristine, and prednisolone chemotherapy. At admission, his white-cell count was . . . [Full Text of this Article]


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