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Previous Volume 359:1175-1177 September 11, 2008 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Patients with spinal cord injury, subcortical stroke, neuromuscular diseases (including amyotrophic lateral sclerosis), and limb amputation have at least two characteristics in common: a brain that wants to direct movement and a body that fails to respond accordingly. Despite intact cortical function, central motor commands in persons with these paralyzing disorders are "disconnected" from their targets, with the neural impulses of intended movement unacknowledged by the downstream central or peripheral nervous system. Pharmacologic, cellular (including stem-cell), and other therapies are designed to repair the injury on-site, but what if the lesion could simply be bypassed, thereby providing a new pathway . . . [Full Text of this Article]

Source Information

From the Massachusetts General Hospital and Harvard Medical School — both in Boston; and the Department of Veterans Affairs Rehabilitation Research and Development Service and Brown University — both in Providence, RI.

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