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Correspondence
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Volume 359:1181-1182 September 11, 2008 Number 11
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Aprotinin and Lysine Analogues in High-Risk Cardiac Surgery

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by Ray, W. A.
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by Fergusson, D. A.
-PubMed Citation
To the Editor: Fergusson et al. (May 29 issue)1 report the findings of the Blood Conservation Using Antifibrinolytics in a Randomized Trial (BART) study. They found a negative mortality trend associated with aprotinin as compared with lysine analogues among patients undergoing high-risk cardiac surgery. This trend could be explained by an increased risk of death from a cardiac cause. In contrast to the study by Mangano et al.,2 the BART study revealed no increase in the risk of stroke or renal failure among patients receiving aprotinin.

In an editorial accompanying the article by Fergusson et al., Ray and Stein3 raise . . . [Full Text of this Article]



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