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Correspondence
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Volume 359:1184-1186 September 11, 2008 Number 11
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PTH Mutation with Primary Hyperparathyroidism and Undetectable Intact PTH

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To the Editor: We describe a case of hypercalcemia associated with the secretion of an abnormally truncated parathyroid hormone (PTH) from a parathyroid adenoma. A 59-year-old postmenopausal woman presenting with back pain had an elevated serum calcium level, at 11.8 mg per deciliter (normal range, 8.8 to 10.2), and an intact serum PTH level that was consistently below the limit of detection on two different assays: less than 3 pg per milliliter on Immulite assay (Bio-Mediq DPC) and less than 4 pg per milliliter on Liaison N-tact assay (DiaSorin). Neither PTH-related protein nor paraprotein was detected in serum. Other findings, . . . [Full Text of this Article]



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