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Previous Volume 359:1367-1380 September 25, 2008 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Lung cancer is the leading cause of cancer deaths in the United States¹ and worldwide. The two major forms of lung cancer are non–small-cell lung cancer (about 85% of all lung cancers) and small-cell lung cancer (about 15%). Despite advances in early detection and standard treatment, non–small-cell lung cancer is often diagnosed at an advanced stage and has a poor prognosis. The treatment and prevention of lung cancer are major unmet needs that can probably be improved by a better understanding of the molecular origins and evolution of the disease.

Non–small-cell lung cancer can be divided into three major histologic . . . [Full Text of this Article]

Molecular Origins

Host Susceptibility

Clonal Evolution

Molecular Evolution

EGFR Family

            Ras–Raf–Mek

            PI3K–Akt–mTOR

            LKB1

            TITF1

Angiogenesis

Molecular Profiling

Technical Advances

Gene Profiling

Protein Profiling

Conclusions

Source Information

From the Departments of Thoracic/Head and Neck Medical Oncology (R.S.H., J.V.H., S.M.L.), Cancer Biology (R.S.H., J.V.H.), and Clinical Cancer Prevention (S.M.L.), University of Texas M.D. Anderson Cancer Center, Houston.

Drs. Herbst and Heymach contributed equally to this article.

Address reprint requests to Dr. Lippman at the Department of Thoracic/Head and Neck Medical Oncology, Unit 432, M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, or at slippman@mdanderson.org.

Related Letters:

Lung Cancer
Lutschg J. H., Herbst R. S., Heymach J. V., Lippman S. M.
Extract | Full Text | PDF  
N Engl J Med 2009; 360:87-88, Jan 1, 2009. Correspondence

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