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Editorial
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Volume 359:1395-1398 September 25, 2008 Number 13
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Calcific Aortic Stenosis — Time to Look More Closely at the Valve
Catherine M. Otto, M.D.

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 by Rossebø, A. B.
-PubMed Citation
Calcific aortic stenosis is a progressive disease that results in stiff valve leaflets with eventual obstruction to left ventricular outflow. Once symptoms occur, valve replacement is the only effective treatment, and there are no known therapies to prevent disease progression. However, several lines of evidence suggest that calcific valve disease is not simply due to age-related degeneration but, rather, is an active disease process with identifiable initiating factors, clinical and genetic risk factors, and cellular and molecular pathways that mediate disease progression.

The key initiating factor in the development of calcific aortic stenosis appears to be mechanical stress. Specifically, a . . . [Full Text of this Article]


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From the Division of Cardiology, Department of Medicine, University of Washington, Seattle.


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