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Previous Volume 359:1426-1427 October 2, 2008 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The discovery of the statins by Akira Endo and colleagues in 1976 opened the door to a new era in preventive cardiology.¹ The importance of this discovery was recently underscored by Endo's receipt of the 2008 Albert Lasker Clinical Medical Research Award. By inhibiting the biosynthesis of endogenous cholesterol, the statin drugs lower elevated blood cholesterol levels much more effectively than any of the dietary or drug regimens that were available before Endo's discovery. Moreover, they have proved to be remarkably free of serious side effects.

The hypothesis that elevated blood cholesterol levels represent an important cause of atherosclerosis and . . . [Full Text of this Article]

Source Information

Dr. Steinberg is a professor emeritus, Division of Endocrinology and Metabolism, University of California, San Diego, School of Medicine, La Jolla.

Related Letters:

The Statins in Preventive Cardiology
Newman D. H., Steinberg D.
Extract | Full Text | PDF  
N Engl J Med 2009; 360:541-542, Jan 29, 2009. Correspondence

This article has been cited by other articles:

• Stein, E. A. (2009). Low-Density Lipoprotein Cholesterol Reduction and Prevention of Cardiovascular Disease. Mayo Clin Proc. 84: 307-309 [Full Text]  
• Newman, D. H., Steinberg, D. (2009). The Statins in Preventive Cardiology. NEJM 360: 541-542 [Full Text]