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Correspondence
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Volume 359:1524-1526 October 2, 2008 Number 14
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A Case of Conjugal Azathioprine-Induced Contact Hypersensitivity

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To the Editor: A man in his early 30s presented with an intermittent eczematous eruption over the shaft of his penis and scrotum (Figure 1A). His wife was initially concerned about his fidelity, but a careful history-taking revealed that the rash coincided with his wife's intermittent courses of azathioprine for Crohn's disease. During four courses of such treatment over a 4-year period, her vaginal secretions were yellow, which raised the possibility of secretion of azathioprine or its metabolites that could have led to allergic contact dermatitis in the husband.

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Figure 1. Findings from Examination and Testing of the Patient.

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