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Clinical Implications of Basic Research
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Volume 359:1621-1623 October 9, 2008 Number 15
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Insights into Inflammation and Influenza
Cameron Simmons, Ph.D., and Jeremy Farrar, M.D., D.Phil.

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The emergence of highly pathogenic avian influenza H5N1 viruses in Asia and their spread globally have delivered a timely reminder of the public health and clinical challenges an influenza pandemic would pose. It is remarkable how little patient-oriented clinical research has been conducted over the past 30 years on a disease that could cause such extensive loss of life. There is currently a single oral drug for the treatment of influenza (the neuraminidase inhibitor oseltamivir) and no licensed parenteral drugs, although these are being developed. A key therapeutic question recently addressed by Zheng et al.1 in an animal model is . . . [Full Text of this Article]


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From the Hospital for Tropical Diseases, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.



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