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Previous Volume 359:1700-1707 October 16, 2008 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's clinical recommendations.

A 53-year-old man, who is otherwise healthy and has a 20-year history of occasional heartburn, reports having had worsening heartburn for the past 12 months, with daily symptoms that disturb his sleep. He reports having had no dysphagia, gastrointestinal bleeding, or weight loss and in fact has recently gained 20 lb (9 kg). What would you advise regarding his evaluation and treatment?

The Clinical Problem

. . . [Full Text of this Article]

Strategies and Evidence

Diagnosis

Lifestyle Modifications

Medication

Surgery

Areas of Uncertainty

Guidelines from Professional Societies

Conclusions and Recommendations

Source Information

From the Division of Gastroenterology, Feinberg School of Medicine, Chicago.

An audio version of this article is available at www.nejm.org.

Address reprint requests to Dr. Kahrilas at the Feinberg School of Medicine, 676 St. Clair St., Suite 1400, Chicago, IL 60611-2951, or at p-kahrilas@northwestern.edu.

Related Letters:

Gastroesophageal Reflux Disease
Aguirre C., Ruiz-Irastorza G., Egurbide M.-V., Fernández-Fernández F. J., Kahrilas P. J.
Extract | Full Text | PDF  
N Engl J Med 2009; 360:729-730, Feb 12, 2009. Correspondence

This article has been cited by other articles:

• Aguirre, C., Ruiz-Irastorza, G., Egurbide, M.-V., Fernandez-Fernandez, F. J., Kahrilas, P. J. (2009). Gastroesophageal Reflux Disease. NEJM 360: 729-730 [Full Text]  
• Pollok, R. C.G., Baierlein, S. A., Wistop, A., Della-Torre, E., Dagna, L., Saporiti, N., Coulter, D. M., Kelly, C. P., LaMont, J. T. (2009). Clostridium difficile. NEJM 360: 636-638 [Full Text]