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Previous Volume 359:1838-1841 October 23, 2008 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Multiple sclerosis is a cruel disease. It strikes young adults, runs a chronic, unpredictable course, and is eventually disabling for many patients.¹ Both inherited and environmental factors influence the risk and course of the disease.² Multiple sclerosis is one of the great unsolved mysteries in modern medicine, with a number of striking epidemiologic features, including an increasing global frequency, an inverse relationship between serum 25-hydroxyvitamin D levels and disease risk, and a tantalizing association with Epstein–Barr virus infection.

Multiple sclerosis usually begins as a relapsing–remitting disease, but in most patients a steadily progressive neurologic disorder ultimately ensues. As a general . . . [Full Text of this Article]

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From the Department of Neurology, University of California, San Francisco, San Francisco.

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