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Previous Volume 359:2068-2069 November 6, 2008 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Gray et al. (July 10 issue)¹ report that the Three Interventions in Cardiogenic Pulmonary Oedema (3CPO) trial showed no benefit from noninvasive ventilation for reducing the intubation rate or short-term mortality. These findings are of concern and appear to conflict with previous trial data.^2,3

This trial may be biased and lack generalizability for several reasons. First, sick patients, who required "lifesaving or emergency intervention" and might have benefited most, were excluded. Second, 19.4% of patients did not complete their assigned treatment. Third, there was considerable cross-contamination among the treatment groups.

Furthermore, there were no objective criteria for . . . [Full Text of this Article]

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