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Previous Volume 359:2283-2285 November 20, 2008 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Vaccination with live attenuated virus can be highly effective for the induction of protective immunity and is critical in the prevention of once devastating epidemic diseases. Vaccines containing live attenuated virus offer more effective and lasting immunity at a much lower dose and, therefore, at a lower cost of production than inactivated vaccines.¹

However, such vaccines are not without drawbacks. First, the creation of a strain of virus that can be grown readily and replicates well enough in vivo to stimulate a protective immune response and yet does not cause disease is more art and guesswork than science. Indeed, vaccines . . . [Full Text of this Article]

Source Information

From the Department of Molecular Biology and Microbiology, Tufts University, Boston.

This article has been cited by other articles:

• Plotkin, S. A. (2009). Vaccines: the Fourth Century. CVI 16: 1709-1719 [Abstract] [Full Text]