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Previous Volume 359:2379-2381 November 27, 2008 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The recent coming of age of genomic techniques and bioinformatics tools has led to an unprecedented proliferation of publications on genomewide association studies and expression profiling for use in genetic analysis, molecular classification, and prognostication of various diseases. Such reports, however, have often resulted in confusion and, at times, disappointment. The use of expensive methods to subclassify histologic variants of tumors as accurately as $15 immunohistochemical assays, the inability to replicate more than 98% of published genomewide association studies, and multiple retrospective studies using single-group series with small sample sizes all contribute to these sentiments. For these reasons, the article . . . [Full Text of this Article]

Source Information

From the Genomic Medicine Institute, Cleveland Clinic, and the Department of Genetics, Case Western Reserve University School of Medicine, Cleveland.

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