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Previous Volume 359:2468-2476 December 4, 2008 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented. The article ends with the author's clinical recommendations.

A 62-year-old man presents with weakness and impaired coordination. The physical examination discloses a resting tremor of the right hand, with mild rigidity at the right wrist, and a slow, shuffling gait. The patient is referred to a neurologist, . . . [Full Text of this Article]

The Clinical Problem

Pathophysiology and Effect of Therapy

Clinical Evidence

Clinical Use

Adverse Effects

Areas of Uncertainty

Guidelines

Recommendations

Source Information

From the Department of Neurology, Henry Ford Hospital, and the Department of Neurology, Wayne State University School of Medicine — both in Detroit.

Address reprint requests to Dr. LeWitt at the Henry Ford Health Systems–Franklin Pointe Medical Center, 26400 W. Twelve Mile Rd., Suite 115, Southfield, MI 48034, or at palewitt@ameritech.net.

Related Letters:

Levodopa for Parkinson's Disease
Devos D., Moreau C., Destée A., Gérard J. M., Elosegi J.-A., LeWitt P. A.
Extract | Full Text | PDF  
N Engl J Med 2009; 360:935-936, Feb 26, 2009. Correspondence

This article has been cited by other articles:

• Devos, D., Moreau, C., Destee, A., Gerard, J. M., Elosegi, J.-A., LeWitt, P. A. (2009). Levodopa for Parkinson's Disease. NEJM 360: 935-936 [Full Text]