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Correspondence
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Volume 359:2502-2504 December 4, 2008 Number 23
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Osteosarcoma Derived from Donor Stem Cells Carrying the Norrie's Disease Gene

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To the Editor: There have been few reports of osteosarcoma after allogeneic bone marrow transplantation.1 We report the development of osteosarcoma in a recipient 17 years after stem-cell transplantation.

A 23-month-old boy with β-thalassemia received a bone marrow transplant from his HLA-identical 11-year-old brother in September 1989. Norrie's disease had been diagnosed in the donor at 12 months of age, after enucleation of the right eye was performed because a bilateral retinoblastoma was suspected. No genetic analysis was conducted at the time of surgery. Norrie's disease is an X-linked recessive disease caused by mutations in the NDP gene on Xp11.4.2 . . . [Full Text of this Article]



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