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Previous Volume 359:2599-2601 December 11, 2008 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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An effective human malaria vaccine has been sought for over 70 years, with little success.¹ A successful malaria vaccine used in conjunction with other control interventions would help reduce and eventually eliminate the considerable global disease burden caused by malaria. Many different antigens have been identified as potential targets for malaria-vaccine development. One of these, the repetitive sequence of four amino acids in the circumsporozoite antigen on the surface of the sporozoite of Plasmodium falciparum, arguably the most important of the human malarias, is the basis for the RTS,S vaccine.² This vaccine was subjected to extensive studies involving human volunteers, . . . [Full Text of this Article]

Source Information

From the Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta. The opinions expressed in this article are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.

This article (10.1056/NEJMe0808983) was published at www.nejm.org on December 8, 2008.

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