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Editorial
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Volume 359:2603-2604 December 11, 2008 Number 24
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Energy In, Energy Out, and the Effects of Obesity-Related Genes
Rudolph L. Leibel, M.D.

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by Cecil, J. E.
-PubMed Citation
More than 100 genes have been implicated in the determination of body weight. These genes, acting primarily in or through the central nervous system (primarily the hypothalamus and brain stem), affect conscious and unconscious aspects of food intake and energy expenditure. They include genes mediating brain sensing of fat stores, calorie flux in the gut, hedonic responses to specific foods, rates of energy expenditure, and even inclination to physical activity.1,2,3 In some populations, mutations in one of these genes — the melanocortin 4 receptor (MC4R), which conveys hypothalamic signals suppressing food intake and increasing energy expenditure — can . . . [Full Text of this Article]


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From the Division of Molecular Genetics and Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York.



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