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Volume 359:2842-2844 December 25, 2008 Number 26
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Accuracy of CT Colonography for Colorectal Cancer Screening

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by Fletcher, R. H.
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by Johnson, C. D.
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To the Editor: Johnson et al. (Sept. 18 issue)1 discuss the use of computed tomographic (CT) colonography as a noninvasive option in screening for colorectal cancer, with optical colonoscopy and histologic review serving as the reference standard. Two important points merit discussion. First, sensitivities that are reported in the "per-polyp" analysis for lesions measuring 5 to 9 mm in diameter are deceiving since values are reported as "greater than or equal to" a certain size. With this method, a higher sensitivity for larger lesions falsely elevates the sensitivity for smaller ones. Using data abstracted from Table 3 and Table 4 . . . [Full Text of this Article]



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