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Previous Volume 359:2847-2848 December 25, 2008 Number 26 Next

Cardiac Amyloidosis with the E526V Mutation of the Fibrinogen A -Chain

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To the Editor: Proteinuria developed in a 48-year-old man in 2003. His mother had died 10 years earlier from renal amyloidosis. Laboratory tests showed isolated nephrotic-range proteinuria (urinary protein excretion, >7 g per 24 hours) with normal creatinine clearance (estimated glomerular filtration rate with the use of the Modification of Diet in Renal Disease equation, 96 ml per minute per 1.73 m² of body-surface area); no monoclonal gammopathy was found. A specimen from a renal biopsy contained amyloid deposits located exclusively in the mesangium of the glomeruli (Figure 1A). The hereditary transmission of the disease led us to . . . [Full Text of this Article]

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