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Previous Volume 359:285-292 July 17, 2008 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented. The article ends with the author's clinical recommendations.

A 25-year-old man presents to the emergency department with a toothache. During the evaluation, the physician determines that the patient has been taking large doses of over-the-counter acetaminophen along with an acetaminophen–hydrocodone product for the past 5 days. His . . . [Full Text of this Article]

The Clinical Problem

Pathophysiology and Effect of Therapy

Clinical Evidence

Clinical Use

Adverse Effects

Areas of Uncertainty

Guidelines

Recommendations

Source Information

From Rocky Mountain Poison and Drug Center, Denver Health, and the University of Colorado Denver School of Medicine — both in Denver.

Address reprint requests to Dr. Heard at the Rocky Mountain Poison and Drug Center, Denver Health, 777 Bannock St., MS 0180, Denver, CO 80208, or at kennon.heard@rmpdc.org.

Related Letters:

Acetaminophen Poisoning
Mégarbane B., Deye N., Baud F. J., Farmer B. M., Hoffman R. S., Dear J. W., Waring W. S., Bateman D. N., Nogué-Xarau S., Castanyer-Puig B., Barceló-Martín B., Goldberg J. B., Leiner S., Heard K. J.
Extract | Full Text | PDF  
N Engl J Med 2008; 359:1962-1965, Oct 30, 2008. Correspondence

This article has been cited by other articles:

• Megarbane, B., Deye, N., Baud, F. J., Farmer, B. M., Hoffman, R. S., Dear, J. W., Waring, W. S., Bateman, D. N., Nogue-Xarau, S., Castanyer-Puig, B., Barcelo-Martin, B., Goldberg, J. B., Leiner, S., Heard, K. J. (2008). Acetaminophen Poisoning. NEJM 359: 1962-1965 [Full Text]