Primary liver cancer is the fifth most common cancer worldwideand the third most common cause of death from cancer, resultingin more than 600,000 deaths per year. The major risk factorsfor hepatocellular carcinoma are chronic hepatitis B or hepatitisC virus infection, alcoholic cirrhosis, and nonalcoholic steatohepatitis.1Cancer probably develops in the cirrhotic liver through theinduction of accelerated cycles of cell injury, death, and regenerationin an altered fibrotic and inflammatory microenvironment. Abnormalimmortalized cell clones arise, and these cells develop geneticand epigenetic alterations that provide a survival and proliferativeadvantage, resulting in unconstrained proliferation, a . . . [Full Text of this Article]
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From the Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester, MN.
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