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Volume 359:539-541 July 31, 2008 Number 5
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Cytomegalovirus Immunity after Vaccination with Autologous Glioblastoma Lysate

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To the Editor: Glioblastoma is a malignant brain tumor with overall survival rates of less than 3.3% at 5 years.1 Few effective treatments are available. The durability of a radiographically defined response to treatment is limited, and median survival is less than 2 years.

We are conducting a phase 1 trial of autologous dendritic-cell vaccination as adjunctive therapy in glioma, a study that has been approved by the institutional review board at the University of California, Los Angeles. All patients are treated with surgery, standard radiotherapy, and temozolomide, followed by vaccination with dendritic cells that are pulsed with an autologous . . . [Full Text of this Article]


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