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Previous Volume 359:766-768 August 14, 2008 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The precise localization of some insulinomas (islet-cell adenomas that secrete insulin) with the use of conventional imaging techniques, such as computed tomography (CT), magnetic resonance imaging (MRI), endosonography,¹ and indium-111 (¹¹¹In)–labeled pentetreotide scintigraphy (OctreoScan),² is a challenging clinical problem. In vitro studies have demonstrated that receptors for glucagon-like peptide 1 (GLP-1) are highly overexpressed in almost all insulinomas.^3,4 Therefore, GLP-1-like radioligands retaining high binding affinity to GLP-1 receptors have been developed. One such radioligand, [Lys⁴⁰(Ahx-DTPA-¹¹¹In)NH₂]exendin-4, successfully targeted insulinomas in the Rip1-Tag2 mouse.⁵ We evaluated the diagnostic value of GLP-1–receptor scintigraphy in two patients . . . [Full Text of this Article]

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