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Case Records of the Massachusetts General Hospital
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Volume 359:842-853 August 21, 2008 Number 8
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Case 26-2008 — A 26-Year-Old Woman with Headache and Behavioral Changes
Thomas D. Sabin, M.D., Jeffrey A. Jednacz, M.D., and Paul N. Staats, M.D.

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Presentation of Case

Dr. Thomas J. Cummings, Jr. (Psychiatry): A 26-year-old woman was admitted to this hospital because of headache, behavioral changes, abnormal movements, and inability to communicate. The patient had been well, except for occasional migraine headaches, until 7 weeks earlier, when generalized, diffuse headache developed. It was most severe in the occipital region, with associated neck stiffness, sensitivity to sounds, intermittent blurred vision, nausea, and vomiting. There were no prodromal symptoms or visual scotoma, which had occurred routinely with her migraines, and the pain did not diminish in response to her usual migraine treatment. During the next 10 days, she . . . [Full Text of this Article]

Differential Diagnosis

Important Features of the History

Localization

Viral Infections

Systemic Autoimmune or Vasculitic Diseases

Hashimoto's Encephalopathy

Whipple's Disease

Inflammatory Limbic Encephalitis

Clinical Diagnosis

Dr. Thomas D. Sabin's Diagnosis

Pathological Discussion

Anatomical Diagnosis


Source Information

From the Department of Neurology, Tufts Medical Center (T.D.S.); the Departments of Radiology (J.A.J.) and Pathology (P.N.S.), Massachusetts General Hospital; the Department of Neurology, Tufts University School of Medicine (T.D.S.); and the Departments of Radiology (J.A.J.) and Pathology (P.N.S.), Harvard Medical School — all in Boston.




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