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Dr. Thomas J. Cummings, Jr. (Psychiatry): A 26-year-old woman was admitted to this hospital because of headache, behavioral changes, abnormal movements, and inability to communicate. The patient had been well, except for occasional migraine headaches, until 7 weeks earlier, when generalized, diffuse headache developed. It was most severe in the occipital region, with associated neck stiffness, sensitivity to sounds, intermittent blurred vision, nausea, and vomiting. There were no prodromal symptoms or visual scotoma, which had occurred routinely with her migraines, and the pain did not diminish in response to her usual migraine treatment. During the next 10 days, she
Differential Diagnosis
Important Features of the History
Localization
Viral Infections
Systemic Autoimmune or Vasculitic Diseases
Hashimoto's Encephalopathy
Whipple's Disease
Inflammatory Limbic Encephalitis
Clinical Diagnosis
Dr. Thomas D. Sabin's Diagnosis
Pathological Discussion
Anatomical Diagnosis
Source Information
From the Department of Neurology, Tufts Medical Center (T.D.S.); the Departments of Radiology (J.A.J.) and Pathology (P.N.S.), Massachusetts General Hospital; the Department of Neurology, Tufts University School of Medicine (T.D.S.); and the Departments of Radiology (J.A.J.) and Pathology (P.N.S.), Harvard Medical School — all in Boston.
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