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Editorial
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Volume 359:858-860 August 21, 2008 Number 8
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Preeclampsia — A Glimpse into the Future?
Ravi Thadhani, M.D., M.P.H., and Caren G. Solomon, M.D., M.P.H.

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 by Vikse, B. E.
-PubMed Citation
Preeclampsia, a disorder of pregnancy characterized by elevated blood pressure and proteinuria, complicates approximately 5% of pregnancies.1 Although several risk factors for this condition are well recognized, including nulliparity, extremes of maternal age, obesity, and preexisting diabetes or hypertension, the causes of preeclampsia remain uncertain; recent studies have suggested that circulating angiogenic factors, alterations in the renin–angiotensin system, and insulin resistance may be involved in pathogenesis.1 Despite several trials examining various interventions,1 no strategy has proved effective in the prevention or treatment of preeclampsia other than delivery of the fetus. Complications include maternal stroke, renal failure, and placental abruption; offspring . . . [Full Text of this Article]


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From the Renal Unit and Department of Medicine, Massachusetts General Hospital, Boston (R.T.).


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