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Correspondence
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Volume 359:870-871 August 21, 2008 Number 8
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More on Serotonin Syndrome Associated with Triptan Monotherapy

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To the Editor: The letter by Soldin and Tonning regarding the association between the serotonin syndrome and triptan monotherapy (May 15 issue)1 requires clarification. On the basis of an analysis of 27 cases from the Adverse Event Reporting System (AERS), the Food and Drug Administration (FDA) issued an alert, "Potentially Life-Threatening Serotonin Syndrome with Combined Use of SSRIs [selective serotonin reuptake inhibitors] or SNRIs [selective serotonin–norepinephrine reuptake inhibitors] and Triptan Medications."2 After receiving a Freedom of Information Act request, the FDA provided me with data on 29 cases that they evaluated as the basis for the alert. My analysis revealed . . . [Full Text of this Article]


Related Letters:

Serotonin Syndrome Associated with Triptan Monotherapy
Soldin O. P., Tonning J. M., the Obstetric–Fetal Pharmacology Research Unit Network
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N Engl J Med 2008; 358:2185-2186, May 15, 2008. Correspondence



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