Now well into the third decade of the pandemic of human immunodeficiencyvirus (HIV) and AIDS, we have seen dramatic successes in thetreatment of HIV-infected persons in the United States and manyother countries. Yet the pandemic still rages, with 2.7 millionnew infections in 2007. Indeed, for every infected person whobegan receiving antiretroviral therapy in 2007, 2.5 people werenewly infected with HIV. Historically, vaccines have been amongthe most effective public health interventions, preventing thespread of viral infections. But an HIV vaccine has thus farbeen elusive and the quest disappointing and frustrating, promptingsome . . . [Full Text of this Article]
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Dr. Johnston is the director of the Vaccine Research Program in the Division of AIDS, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, and Dr. Fauci is the director of NIAID.
An interview with Anthony Fauci is available at www.nejm.org
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