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Previous Volume 359:928-937 August 28, 2008 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Acute upper gastrointestinal hemorrhage, which is defined as bleeding proximal to the ligament of Treitz, is a prevalent and clinically significant condition with important implications for health care costs worldwide. Negative outcomes include rebleeding and death, and many of the deaths are associated with decompensation of coexisting medical conditions precipitated by the acute bleeding event.¹ This review focuses specifically on the current treatment of patients with acute bleeding from a peptic ulcer.

Epidemiology

The annual rate of hospitalization for acute upper gastrointestinal hemorrhage in the United States is estimated to be 160 hospital admissions per 100,000 population, which translates into more . . . [Full Text of this Article]

Clinical Presentation

Initial Management

Patient Triage and Risk Stratification

Approach to Therapy

Patients at High Risk

Patients at Low Risk

Medical Therapy

Surgery and Interventional Radiology

Source Information

From the Department of Gastroenterology and Gastrointestinal Outcomes Unit, Rambam Health Care Campus and Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel (I.M.G.); the Divisions of Gastroenterology and Clinical Epidemiology, McGill University Health Centre, McGill University, Montreal (A.N.B.); and INSERM Centre d'Investigations Cliniques Plurithématique, Centre Hospitalier Universitaire du Bocage and Institut Fédératif de Recherche Santé, Sciences et Techniques de l'Information et de la Communication, Université de Bourgogne — both in Dijon, France (M.B.).

An animation showing endoscopic management of acute bleeding from a peptic ulcer is available with the full text of this article at www.nejm.org.

Address reprint requests to Dr. Gralnek at the Department of Gastroenterology and Gastrointestinal Outcomes Unit, Rambam Health Care Campus, Bat Galim, Haifa 31096, Israel, or at i_gralnek@rambam.health.gov.il.

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