To the Editor: We report on a patient with type 1 diabetes mellitus,diagnosed at 16 years of age, in whom widespread amyloid depositsdeveloped many years later in transplanted human islets. Theislets were administered through three intraportal infusions:two infusions were administered 4 months apart when the patientwas 50 years of age, and one infusion was administered whenhe was 54 years of age.
Before the first implantation, the treatment of the patient,who had a functioning renal transplant, was switched to theEdmonton immunosuppression protocol (i.e., daclizumab, tacrolimus,and sirolimus). After the second islet transplantation, the. . . [Full Text of this Article]
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